Neoreviews Subscribe to Pediatrics in Review
HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Take the CME quiz:
 Vol. 9 No. 5, May 2008
Right arrow E-Letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-Letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My File Cabinet
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via CrossRef
Google Scholar
Right arrow Articles by Brodsky, D.
PubMed
Right arrow Articles by Brodsky, D.

NeoReviews Vol.9 No.5 2008 e218
© 2008 American Academy of Pediatrics

Intrauterine Immunoglobulin in the Prevention of Neonatal Hemochromatosis

Dara Brodsky, MD*

* Neonatologist, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass

Neonatal hemochromatosis (NH), although rare, is the most common cause of liver failure in the neonate. This disorder is associated with extrahepatic siderosis and has been called neonatal iron storage disease. The pathogene sis was a mystery until 2004, when Peter Whitington hypothesized that NH may be an immune-mediated disorder. Clinical and laboratory findings demonstrate liver failure but usually are nonspecific. Evidence of extrahepatic siderosis by magnetic resonance imaging with decreased intensity of T2-weighted sequences of specific organs confirms the diagnosis. Treatment of NH is challenging, and survival rates are dismal despite medical agents (ie, iron chelators and antioxidants) or liver transplantation. Recently, NH has been prevented in subsequent pregnancies by administering intrauterine immunoglobulin to pregnant women, changing NH from a lethal to a nonlethal disease.






HOME HELP CONTACT US SUBSCRIPTIONS CME ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Academy of Pediatrics.