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 Vol. 9 No. 4, April 2008
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NeoReviews Vol.9 No.4 2008 e150
© 2008 American Academy of Pediatrics

Renal Developmental Physiology

Relevance to Clinical Care

Lisa K. Kelly, MD*
Istvan Seri, MD, PhD*

* Center for Fetal and Neonatal Medicine at Childrens Hospital Los Angeles and the USC Division of Neonatal Medicine, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, Calif

Effective management of fluid and electrolyte homeostasis for the critically ill neonate requires a general understanding of renal development and changes that occur during the transition from the intrauterine to extrauterine environment. The maturation of kidney function and differences in regulation of body fluid tonicity and volume as well as acid-base balance and homeostasis of individual elements between preterm and term infants can have a substantial impact on therapies administered to neonates and the effects of such therapies.






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