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 Vol. 9 No. 3, March 2008
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NeoReviews Vol.9 No.3 2008 e119
© 2008 American Academy of Pediatrics

Hemostasis in the Neonate

Marilyn J. Manco-Johnson, MD*

* Professor of Pediatrics, University of Colorado, Denver, and the Children's Hospital, Denver, Colo

The coagulation system is finely tuned to arrest bleeding at the site of vascular injury and quickly remove clots that obstruct blood flow. In the fetus, components of the coagulation system show unique developmentally regulated patterns and times for maturation to normal adult protein quantities and functions. In addition, several coagulation proteins contribute to cellular proliferation and differentiation uniquely during fetal life. In spite of this, results of most screening tests of hemostasis vary modestly from adult normal values in the healthy term infant, and both hemorrhage and thrombosis are rare in the well infant.






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Copyright © 2008 by the American Academy of Pediatrics.